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mastitis
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Practice scenario: breast soreness in a breastfeeding mother

Mrs Alexander is a new mum. She has been struggling with breastfeeding, has experienced pain when the baby latches on, and has woken this morning with a painful left breast.

Mrs Alexander comes into the pharmacy for some advice. She is a new mum and has a 2-week-old daughter. For the last few days she has been struggling with breastfeeding and has experienced pain when the baby latches on. 

However, she woke up this morning with a painful left breast. She contacted the GP practice to try to speak to the health visitor, but nobody seems to be answering the phone. She thought she’d pop into the pharmacy as she has no one else to ask for advice. 

She describes breastfeeding as difficult and painful and tells you that if the symptoms don’t improve she is thinking of giving up breastfeeding, although she really wants to continue as she knows it is good for her and her baby. She asks you what she can do to help with the pain and discomfort when feeding.

Key points: Mastitis
  • Milk stasis is the main cause of mastitis
  • Poor infant attachment is a contributing cause to developing mastitis
  • Recovery tends to be rapid, but complications may occur (e.g. infection and abscess)

Problem representation

Breastfeeding mother presents with an acute history of soreness in her left breast, together with breastfeeding difficulties.

Hypothesis generation

Breast soreness in lactating women is mostly attributable to mastitis with up to 30% of them experiencing it. Mastitis is defined as inflammation of the breast, and while it can occur at any time during lactation, it is most common in the first four to six weeks of breastfeeding. However, it can also occur in women who are not lactating. 

Milk stasis/milk drainage is the primary cause and is commonly associated with poor infant attachment to the breast or poor feeding. It can also be precipitated through an abundant supply of breastmilk, missed or reduced number of feeds, or the use of nipple shields. 

Mastitis should be suspected in women presenting with segmental breast pain, and a swollen, red and tender breast with associated flu-like symptoms (fever/malaise).

Underlying infection is uncommon and symptoms settle with conservative management. Mastitis can lead to the discontinuation of breastfeeding.

Likely diagnoses

  • Mastitis (non-infective)

 Possible diagnoses

  •  Breast abscess
  • Compressed ducts
  • Full or engorged breasts
  • Galactocele
  • Non-lactational mastitis (not applicable in this case)

 Critical diagnoses

  •  Breast cancer

Aide Memoire

Likely diagnoses

Mastitis
Mastitis usually occurs in one breast but may affect both. Symptoms usually develop quickly and include a swollen area that can be hot, red and painful (which can be severe) to the touch. On darker skin tones there might be a darkening of the skin. Nipple discharge maybe seen. Flu-like symptoms, for example feeling tired and achy, and having a fever and chills is common. Signs of skin retraction may also be present e.g. breast dimpling, nipple deviation, or inversion.

Possible diagnoses

Breast abscess
A breast abscess is usually a complication of mastitis and has similar symptoms, however the skin may have an ‘orange peel’ appearance and there is generally a lump or swelling in the breast which is not relieved by feeding.
Compressed duct
Symptoms of a blocked milk duct tend to come on gradually and affect a localised area of one breast. Discomfort is experienced over the area, which may be relieved by milk expression. The skin may be red, and a ‘bleb’ (small white spot/blister) may be present at the end of the nipple. Systemic symptoms are not seen.
Full or engorged breasts
Full or engorged breasts: can occur when the breasts are being ineffectively drained. Typically experienced shortly after childbirth where both breasts feel hot, heavy and hard and symptoms are worse before feeds. The whole breast tends to be swollen and oedematous and may leak excessively.
Galactocoele
Galactoceles most commonly form following breastfeeding cessation but may occur during active breastfeeding. It is due to a persistent obstruction of the lactiferous duct results and presents as firm, well defined (round) painless breast swelling, which causes milky nipple discharge when pressed. Systemic symptoms are absent.
Non-lactational causes
Non-lactational mastitis includes conditions such as periductal mastitis (PDM) and idiopathic granulomatous mastitis (IGM), both of which are chronic inflammatory diseases.
Periductal mastitis
PDM affects the ducts near the nipple and is often seen in younger women. Features of PDM include a periareolar or subareolar mass, which may be associated with pain and erythema. Acute PDM resembles mastitis as the affected breast is red, swollen, warm, and painful. Systemic symptoms, including fever and malaise. Smoking is a significant risk factor.
Idiopathic granulomatous mastitis
This is uncommon and poorly understood inflammatory breast condition. IGM typically presents as a tender, red, and unilateral soft breast mass that can occur in any breast quadrant except for the region beneath the areola. Common symptoms include nipple discharge, skin changes such as ulcers, and enlargement of the axillary lymph nodes. Systemic symptoms beyond the breast are often seen such as joint swelling and pain.

Critical diagnoses

Breast Cancer (inflammatory)
This is a rare type of breast cancer that can appear suddenly and may mimic the signs and symptoms of mastitis.

Continued information gathering 

We know Mrs Alexander has unilateral breast soreness. This allows us to rule out breast engorgement, as this involves both breasts. Mastitis is the most likely cause and knowing if Mrs Alexander has systemic symptoms would allow us to rule out a compressed duct or galactocele. She reports that she feels off colour and feverish, so this reinforces our thinking that she is suffering from mastitis.

Problem refinement

Breast abscess is still a possibility, but it usually follows mastitis. Asking about a recent history of similar symptoms should establish if this is a first-time presentation, or if Mrs Alexander has a history of similar symptoms. She confirms this the first time she has had this problem.

It appears we are dealing with mastitis.

Red flags

Checking for signs of infection is necessary. Purulent nipple discharge, severe pain, and signs of spreading cellulitis suggest infection. Our patient has not observed these symptoms.

Management

Self-care options

Mastitis can usually be treated with self-care measures. For Mrs Alexander, a number of strategies can be employed to help resolve symptoms. These include: 

  • Make sure the baby is attached properly (see Table 1 below)
  • Use a cold compress every 10 minutes to help with pain
  • Continue to breastfeed - if breastfeeding is too painful, or the infant refuses to breastfeed from the affected breast, then advise her to hand express sufficient milk to match the infant needs
  • Take analgesia for pain and fever.
Table 1: Assessing if your baby is well attached
• Check if the baby’s chin is firmly touching the breast
• Check if the baby’s mouth is wide open
• Check if the baby has a large mouthful of breast
• Check if the baby’s cheeks stay rounded during sucking
• Your baby rhythmically takes sucks and swallows
• Your baby finishes the feed and comes off the breast on his or her own
• No change in shape or colour of the nipple after feeds

Prescribing options

Antibiotics may be considered if there are no improvements in symptoms after 24 hours of self-care measures. The antibiotic of choice is flucloxacillin 500 mg four times daily for 10-14 days (erythromycin or clarithromycin should be prescribed if they have a confirmed allergy to penicillin). 

Safety netting

You tell Mrs Alexander that she appears to have mastitis and by following some self-care measures her symptoms should settle down over the next 24 hours, but if symptoms do not improve or worsen she should return as she may have an infection and antibiotics would be needed.  

Complete the following multiple choice questions to test your understanding:

1. A 28-year-old lactating woman presents with fever, breast pain, and localised redness. Which ONE of the following findings is most suggestive of lactational mastitis?
(a) Bilateral, painless breast enlargement
(b) Bloody nipple discharge
(c) Diffuse breast tenderness without skin changes
(d) Firm, non-tender breast mass
(e) Localised erythema with warmth and systemic symptoms

2. Which ONE of the following organisms is most associated with infectious mastitis?
(a) Escherichia coli
(b) Mycobacterium tuberculosis
(c) Staphylococcus aureus
(d) Streptococcus pneumoniae
(e) Pseudomonas aeruginosa

3. In non-lactational mastitis, which ONE of the following factors is most associated with its development?
(a) Excessive breastfeeding
(b) Family history of breast cancer
(c) High oestrogen levels
(d) Smoking
(e) Use of oral contraceptives

4. A 35-year-old woman presents with breast redness and swelling for 10 days. She is not breastfeeding and has no fever. The skin shows erythema but no tenderness. Symptoms have not improved with antibiotics. Which ONE of the following should be considered as the most likely diagnosis?
(a) Acute mastitis
(b) Breast abscess
(c) Galactocele
(d) Inflammatory breast cancer
(e) Simple breast cyst

5. A 27-year-old breastfeeding woman presents with breast pain, fever, and malaise. Which ONE of the following helps confirm the diagnosis of mastitis rather than a blocked duct?
(a) Absence of nipple discharge
(b) Bilateral breast involvement
(c) History of breastfeeding
(d) Firm breast consistency
(e) Presence of systemic symptoms

Answers:
1. E  2. C  3. D  4. D  5. E

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